1.2 Designing Covalent Inhibitors: A Medicinal Chemistry Challenge

Chapters in this book

1. Frontmatter I
2. Contents V
3. Preface XI
4. Section 1: Chemical Principles in Drug Design and Discovery
5. 1.1 Functional Groups of Biomolecules and their Reactions 2
6. 1.2 Designing Covalent Inhibitors: A Medicinal Chemistry Challenge 44
7. Section 2: Chemical Basis of Drug Action and Diseases
8. 2.1 Pharmacokinetics and Bioanalysis to Improve Drug Development 62
9. 2.2 Translational Research in Endocrinology and Neuroimmunology Applied to Depression 119
10. 2.3 Understanding the Metabolic Syndrome Using a Biomedical Chemistry Profile 132
11. 2.4 Brain Neurochemistry and Cognitive Performance: Neurotransmitter Systems 148
12. Section 3: Strategies to Develop New and Better Drugs
13. 3.1 Amino Acids and Peptides in Medicine: Old or New Drugs? 178
14. 3.2 Targeting Calcium-mediated Excitotoxicity in the CNS 229
15. 3.3 Strategies for Conversion of Peptides to Peptidomimetic Drugs 245
16. 3.4 Synthetic Vs. Natural Bioactive Compounds Against Tropical Disease 275
17. 3.5 Current Trends and Developments for Nanotechnology in Cancer 290
18. Index 343